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Structural Biophysical Analysis: Identification of key electrostatic interactions (salt bridges and hydrogen bonds) at the binding interface using distance cutoffs of 4.0 for salt bridges, and a cutoff value of the angle formed by acceptor (A), donor (D) and hydrogen (H) (ADH) of 30 and donor-acceptor (D-A) distance at 3.0 for hydrogen bonds

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Patients should be encouraged to engage in regular moderate-intensity exercise, starting with short durations (10-15 minutes) if necessary and gradually increasing

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