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Carboxylesterase 2 prevents liver steatosis by modulating lipolysis, endoplasmic reticulum stress, and lipogenesis and is regulated by hepatocyte nuclear factor 4 alpha in mice
A 2023 review concludes that L-carnitine supplementation may help to reduce the following: fasting blood sugar levels HbA1c levels, which are the average blood sugar level over 90 days insulin resistance L-carnitine supplements cannot substitute diabetes treatments
it is not an FDA-approved drug
Selective impairment of this carrier-mediated transport can contribute to selective vulnerability of tissues to specific toxins: for example, chronically ethanol-fed hepatocytes become selectively depleted of mitochondrial glutathione because of defective carrier-mediated transport, which makes the hepatocytes susceptible to damage by reactive oxygen species generated from the oxidative metabolism of ethanol (22)
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