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The development of HS donors, prodrugs, and molecules that can specifically target HS production pathways in a controlled and tissue-specific manner will be crucial for advancing clinical applications

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To compare the effects of paraxanthine against caffeine and the impact of age, young 8-week-old (YOUNG) and aged 16-month-old (OLD) rats were evenly divided into four groups ( n = 8 per group): (i) vehicle control (CON), (ii) low-dose paraxanthine (PXN LOW), (iii) high-dose paraxanthine (PXN HIGH), and (iv) high-dose caffeine (CAF HIGH)