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Graphical Abstract 1 Introduction For much of modern drug development, peptide therapeutics were regarded as biologically compelling yet pharmacologically impractical

To this end, 20 l of 20 mg/ml methoxyamine (in anhydrous pyridine) were added to samples, samples were mixed and quickly centrifuged, followed by incubation for 90 min at 30 C

Understanding these mechanisms is essential for both healthcare professionals prescribing weight loss treatments and patients considering over-the-counter supplements, as cardiovascular safety must always be prioritised alongside weight management goals

Outcomes from other smaller trials (reviewed in 89) have suggested either a lack of an effect or the possibility of an increased risk of cancer