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Evening injections should be recommended in order to achieve GH patterns that imitates physiology more closely, however, both morning and evening injections deliver constant supraphysiological doses of GH determined by body weight or surface area, based that do not precisely replicate the natural, pulsatile pattern of GH secretion observed in normal individuals and in individuals with partial GH deficiency ( Our findings join other research challenging the traditional preference for evening injections, which are intended to mimic the natural nocturnal surge in GH secretion
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