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MC1R is the primary melanocortin receptor governing skin pigmentation and expressed on melanocytes, keratinocytes, fibroblasts, and immune cells in the skin , whose activation by -MSH drives melanin synthesis, melanocyte dendritic extension, photoprotective eumelanin production, and anti-inflammatory signalling in response to ultraviolet radiation

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Wadden TA, Tronieri JS, Sugimoto D, Lund MT, Auerbach P, Jensen C, et al

In a recent study on VPA-based rodent model, vitamin C was administered through drinking water (600 mg/L) from early gestation until the end on the third postnatal week, and only male offspring were evaluated