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GLP-1RAs downregulate inducible NOS (iNOS) and dual oxidase 1 (DUOX1), both of which contribute to oxidative stress and epithelial damage [65, 116, 126]

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Some patients initially respond to ICIs but later develop resistance, further emphasizing the need for combination therapies that target multiple MDSC checkpoints to overcome MDSCs driving ICI resistance

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Krivic A, et al

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Studies suggest that the copper(II) ion is essential for biological activity, as the apo-peptide (GHK without copper) shows reduced activity

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