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GLP-1RAs downregulate inducible NOS (iNOS) and dual oxidase 1 (DUOX1), both of which contribute to oxidative stress and epithelial damage [65, 116, 126]
Some patients initially respond to ICIs but later develop resistance, further emphasizing the need for combination therapies that target multiple MDSC checkpoints to overcome MDSCs driving ICI resistance
Krivic A, et al
Studies suggest that the copper(II) ion is essential for biological activity, as the apo-peptide (GHK without copper) shows reduced activity
![glutathione homeostasis PDF] Interactions between biosynthesis, compartmentation and transport in the control of and signalling Glutathione and peroxisome redox homeostasis –](https://figures.semanticscholar.org/73a5b66dee4ce6077e7869e419f514aa490d08c2/2-Figure1-1.png)
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