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SAM is the methyl donor for DNA methyltransferases (DNMT1, DNMT3A, DNMT3B) that maintain methylation patterns at CpG sites, and for the histone methyltransferases (EZH2, SETD2, NSD2) that methylate histones to regulate chromatin state and gene expression

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Cell lines and treatments MCF7, T47D, MDA-MB-231, and 4T1 cells were cultured in RPMI 1640 medium with 3.15 g/L-glucose

Ferroptosis heterogeneity in triple-negative breast cancer reveals an innovative immunotherapy combination strategy