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After being converted to glutamate (Glu) by the enzyme glutaminase (GLS), Gln is further transformed to -ketoglutarate (-KG), entering the mitochondrial tricarboxylic acid (TCA) cycle for energy production

We watch for shifts in mood or energy that overshoot or subtle signaling changes

Oral administration of glutathione alone is thought to be ineffective for altering glutathione levels due to hydrolysis during digestion and poor absorption

Higher resting cerebrovascular tone may occur due to endothelial dysfunction (Bolduc et al., 2013) or chronic overactivity of the sympathetic nervous system (Willie et al., 2014), as seen in cardiovascular disease (Jay Widmer and Lerman, 2014