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We systematically extracted data on primary outcomes (visual acuity, retinal thickness, disease progression) and secondary outcomes (microvascular changes, inflammatory markers, adverse events), capturing all reported time points and analysis methods

In contrast to the lack of brain entry of dopamine in vivo [68], our results with the targeted dopamine-nanoformulation using the BBB model combined with midbrain organoids indicate that the nanoformulation may help dopamine to reach the brain tissue after BBB penetration

doi: 10.1111/j.1751-7915.2008.00070.x 5 BacherP.HohnsteinT.BeerbaumE.RockerM.BlangoM

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