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This randomized, double-blind, placebo-controlled trial in 58 older adults identified as "pre-frail" found an decrease in a Frailty Index score and an improvement in the hand grip test in individuals supplemented with L-carnitine (1.5 g/day) over 10 weeks but not in those given a placebo (118)

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The liver is the principal site for the hydroxylation of cholecalciferol at carbon 25 by 25-hydroxylase enzymes (CYP2R1 and CYP27A1) to form 25(OH)VD 3

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Sci Rep 14 , 24433 (2024)

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