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Pdia3 : Pdia3 is an ER-resident thiol-disulfide oxidoreductase which is modulating Stat3 (signal transducer and activator of transcription) signalling from the lumen of the ER together with Calr [79,80] that might be affected by PD [81]

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Possible clinical applications are women with central obesity, HIV-associated lipodystrophy, or metabolic syndrome in which visceral fat negatively affects reproductive outcomes

The transcription factor binding sites were predicted in The Contra v3 ( [35], and then we re-valued the binding sites using JASPAR ( [36]