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When muscle mass declines, the joint has less protection
For most drugs, clearance is constant over the concentration range encountered in clinical settings, ie, elimination is not saturable, and the rate of drug elimination is directly proportional to concentration (rearranging equation [2]): This is usually referred to as first-order elimination
Many commercial preparations contain additional ingredients such as: Sorbitol or mannitol sugar alcohols used as sweeteners in some tablets that can cause osmotic diarrhoea when consumed in larger quantities, though the amounts in typical supplements are usually too small to cause symptoms alone [13] [14] Binding agents and fillers including lactose, which may cause symptoms in people with lactose intolerance, though tablet quantities are typically small Other additives various excipients that some individuals may be sensitive to The dose and frequency of supplementation may also influence tolerability
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