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The future therefore holds promise for gut hormone-based therapy in the context of both the development of novel drugs and their inclusion in recommendations and guidelines
Genetic factors affecting GLP-1 receptor sensitivity are an area of ongoing research but currently have limited clinical utility for routine care
The work also suggests that the GLP-1R uses the ER as a platform to reach and signal into many different cellular organelles, not just mitochondria
These include reduced neuroinflammation, decreased oxidative stress, enhanced neuronal survival, and improved synaptic plasticity
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