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Early observational data support this possibility, with some patients reporting fewer nodules and less drainage over time

4 The accompanying GOV.UK patient page, last updated in February 2026, sets out the washout periods clearly: semaglutide-based medications need at least two months, tirzepatide (Mounjaro) needs at least one month, and liraglutide can be stopped just before trying because it leaves the body much more quickly

This does not mean lifelong medication is required

Blood sugar improvements from both medications often appear within the first few weeks of treatment, well before significant weight loss occurs