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It is a state of metabolic decompensation
Additionally, GLP-1 suppresses glucagon secretion from pancreatic alpha cells, slows gastric emptying to moderate the rate at which nutrients enter the bloodstream, and acts on the brain to promote satiety and reduce appetite
Most patients experience a gradual weight reduction, with the most noticeable results appearing between three and six months of Ozempic use
In reducing the risk of major adverse liver outcomes and HCC, large-scale observational studies and meta-analyses have demonstrated that GLP-1RA and SGLT2i exhibit comparable protective effects, with both showing significant superiority over traditional hypoglycemic agents such as DPP-4i and sulfonylureas
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