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M.BlattL.ChangA
Consent for publication Written informed consent to publish the clinical data was obtained from the patient
Insulin Sensitivity and Blood Glucose Retatrutide's triple mechanism improves glycemic control through multiple pathways: GLP-1 activity stimulates glucose-dependent insulin secretion and suppresses glucagon when blood sugar is high GIP activity enhances insulin sensitivity in adipose tissue and improves nutrient partitioning Glucagon activity paradoxically improves hepatic insulin sensitivity by reducing liver fat and improving hepatic glucose metabolism In the phase 2 type 2 diabetes trial, participants achieved HbA1c reductions of up to 2.02% bringing many into the normal glycemic range
In the Phase 2 trial, fasting glucose increased transiently in some participants, more so at 8 mg and 12 mg, though GLP-1 and GIP co-activation appeared to offset most of this effect
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