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Hormonal shifts: Declines in growth hormone, estrogen, or testosterone affecting metabolism
GLP-1s can suppress appetite enough to lower milk supply, and oral semaglutide's absorption enhancer (SNAC) passes into breast milk, which raises concerns for infants' developing livers
Similarly, in vitro experiments, approximately 45 bacterial phylotypes were identified to enhance GLP-1 secretion through exposure of NCI H716 L-cells to their cell-free culture supernatants (Tomaro-Duchesneau et al., 2020), co-incubation of Caco-2 cells with Enterococcus faecalis or Mitsuokella multacida supernatants led to a significant reduction in GLP-1 mRNA expression ( E
Research should also study whether microbiome changes correlate with gains in gut health outcomes such as reduced swelling, improved barrier function, and symptom resolution
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