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It should also be noted that, from a methodological perspective, the model used (Cox with stratification by cardiovascular risk class of the trials, i.e., SURPASS-4: high risk, and all others: low risk) requires various assumptions, including the homogeneity of the relative effect of tirzepatide treatment on MACE regardless of the baseline cardiovascular risk level of the patients

Rounding into 2023, it was increasingly clear that GLP-1s were not only highly effective medications, but highly charismatic products with broad consumer appeal

Gallbladder Issues : Semaglutide may increase the risk of gallbladder-related problems, such as gallstones

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