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Estos beneficios han sido demostrados en ensayos clnicos especficos para ciertos agentes como liraglutida (LEADER), dulaglutida (REWIND), semaglutida inyectable (SUSTAIN-6) y ms recientemente semaglutida 2.4 mg (Wegovy)

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They showed that while the fasting and post-prandial GLP-1 levels in the pre-RYGB surgery patients were lower than in lean controls, the post-prandial GLP-1 levels became higher post-RYGB, whereas fasting GLP-1 levels did not [22]