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Microbial metabolites like SCFA and Trp derivatives can activate AhR and its target genes, including IL-6, IL-22, prostaglandin G/H synthase 2 (PTGS2), vascular endothelial growth factor A (VEGFA), and cytochrome P450 1 A1 (CYP1 A1) in the intestine or liver
S., Rocha, J
Date: November 16, 2025 Source: Cochrane Summary: GLP-1 drugs like tirzepatide and semaglutide offer powerful weight-loss effects but come with unanswered questions about long-term safety, side effects, and global accessibility
A telehealth platform that does not perform serial pregnancy screening during the course of treatment, something an asynchronous model may not do consistently, creates real risk
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