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Our study revealed that in CG-LSD rats, the hyperactivation of the IL-6/STAT3 signaling pathway could contribute to the sustained inflammatory response and damage to gastric mucosal cells

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The Basement Membrane (BM) composed of extracellular matrix between all the cell types described above, ensures structural support and also contributes to the barrier function of the BBB [Figure 2] Schematic diagram of transverse section in blood-brain barrier illustrating its cellular structures

So about that research: The vast majority of the studies done on Protandim have been done on rats and on cells in lab dishes