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Several current labels carry boxed warnings related to thyroid C-cell tumors in rodents and strongly advise against use in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
The tumor samples were dichotomized based on AFP expression using a cutpoint at the 50 th percentile mark and statistical significance of the differences in metabolite abundance between the groups was determined using a MannWhitney U test in the limma R package 60
The reason this stood out for me is because when I looked up Pickart, he has been working on this molecule for decades
That model applies to reproductive tissues in which cell growth, extracellular matrix repair, and blood flow are important
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