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Yet, while their ability to reduce body weight and insulin levels was greater than GLP1 monotherapy in male models 33,34,35 , the potential of these GLP1-based multi-agonists for the treatment of the metabolic, hormonal, and gonadal complications associated with PCOS has not been explored to date

The Authors reported that treatment with incretins significantly suppressed the FSH-induced synthesis of progesterone through the inhibition of the expression of progestogenic factors and enzymes, whereas there was no significant effect on oestrogen synthesis by rat granulosa cells, thus suggesting the possible role of GLP-1 RA in the treatment of dysregulated steroidogenesis in PCOS [43]

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It is something that Ive once called input-output throughput