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Figure 11 The phosphinic group is, as compared to, e.g., thiols and hydroxamic acids more weakly binding to zinc ions in metalloproteases and a significantly improved selectivity could be achieved by systematic variations of the side chains at P1 and P2 positions of 43

In addition to oxidative stress and mitochondrial metabolic disorders causing cell death, abnormal copper levels can induce cell death through ROS, ER and inflammatory responses (178)

As indicated, despite the tumor-promoting effects of many growth factors and peptides (Gwyer et al., 2019