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The primary outcomes were the percentage weight change and the proportion of participants losing at least 5% of their baseline weight, using treatment-policy estimand analysis (intention-to-treat principle)

Some individuals who are overweight or obese who do not suffer from chronic obesity or certain disorders (such as binge eating disorder or metabolic disorders) may still be able to lose weight through traditional weight loss methods such as lifestyle and diet changes and exercise

Gene set enrichment analysis highlighted the early activation of oxidative stress-related pathways, including oxidative phosphorylation and ROS generation, as early as 1-h post-APAP exposure