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The hepatotoxic effects of APAP are primarily mediated by its bioactivation to the reactive metabolite NAPQI via CYP2E1
The results of disproportionality analysis performed for these medications and SSIBs showed a reporting signal, and studies have suggested that individuals who use these medications may be at a higher risk of SSIBs [46]
While the molecular alterations identified were robust and internally consistent, validation in larger, independent cohorts will be important to confirm our findings and assess inter-individual variability
doi: 10.2337/db11-1824 85 SkovJ
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