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Still, that effect did not replicate at scale in the larger, longer Phase IIb study designed to confirm it which is the standard reason a compounds development gets discontinued rather than a sign the compound is unsafe
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TB-500 works systemically and thus does not need to be administered to a specific target
As an engineered analogue, cagrilintide is designed to mimic key receptor-binding properties of native amylin while incorporating structural modifications that extend its activity and stability in experimental systems
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