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Both peptides enhance cellular antioxidant systemsGHK-CU through direct antioxidant activity and Epithalon through gene expression modulationprotecting against oxidative stress and age-related damage

The concurrent activation of HACD44 and GSHNrf2 signaling axes establishes a dual regulatory network that synchronizes inflammation resolution with oxidative stress mitigation, fostering an optimal biochemical niche for rapid and organized wound closure

The review established DSIP as a pleiotropic neuromodulator rather than a simple sleep factor [2]

With the exception of FOSL1, which was undetectable in all of the samples in the ELISA test, the protein level regulation of IL-1, IL8, HSPA1A by the copper compounds were similar with the gene level regulation