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In November 2025, the administration announced deals with Eli Lilly and Novo Nordisk to provide their GLP-1s at reduced prices

EFFICACY AND SAFETY OF GLP-1 ANALOGS Although there are no studies of the long-term efficacy of DPP-IV inhibitors on -cell function, in short-term studies ranging from several months to 1 year, both sitagliptin and vildagliptin demonstrated a reduction in postprandial plasma glucose concentrations while maintaining plasma insulin response, indicating a positive effect on -cell function [13-15]

Because body composition changes are ultimately driven by sustained energy balance, the durability of appetite suppression becomes a major factor in long-term outcomes

In fibroblast culture models, this upregulation has been associated with measurable telomere elongation a finding that has no equivalent in the peptide research landscape