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only a significant drop in serum LH concentration was detected in mice injected with GLP1/GIP (Suppl

Once those receptors are fully occupied by one medication, adding another does not create more fullness or faster weight loss

The results of several large randomized controlled trials indicated that maintaining blood glucose at near normal concentrations was the most important step in limiting the risk of diabetic neuropathy and lower extremity amputation (70-72)

Access is tightly limited: enrollees need high BMI scores and certain health conditions, while patients using GLP-1s for diabetes or sleep apnea are excluded and must navigate prescriptions and prior authorizations