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Typically no
Do not freeze the pen, and never use it if it has been frozen or exposed to direct heat
More specifically, the superior mesenteric vein, inferior and superior anterior pancreaticoduodenal, pyloric vein, and portal vein in the superior mesenteric vein-portal vein shunt reestablish the interrupted superior mesenteric and portal vein pathway (the occluded end of the superior mesenteric vein) (Vukojevic et al., 2018
Visible degradation signs include color changes (yellowing), cloudiness in reconstituted solution, particulate matter, or visible precipitation
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