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VPS8, a subunit of CORVET complex 26 , plays a critical role in integrin requiring cell adhesion and migration, and recycling of beta-1 integrins 65

There is no consensus about the mechanisms explaining the action of these drugs and more work is therefore needed to elucidate these

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Considering the clinical overlap of these multisystemic clinical syndromes, we will now proceed to summarize aspects of common biomarkers and pathological mechanisms underlying these shared symptoms