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Second, the strength of tirzepatides evidence is exactly what makes an apples-to-apples ranking against an investigational amylin analog impossible: you cannot fairly rank a fully-approved drug against a candidate whose stand-alone efficacy stops at Phase 2
Green JR, Allison KM, Cordella C, Richburg BD, Pattee GL, Berry JD, et al
It targets fat metabolism without the insulin or IGF-1 effects of full growth hormone
By reducing inflammation and metabolic stress, GLP-1 drugs decreased chronic immune activation, a primary driver of accelerated aging in people with HIV
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