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Starting with a low 2.5mg weekly dose helps minimize initial gastrointestinal effects like nausea and diarrhea

KPV: 500 to 1,500 mcg per day orally, or 200 to 500 mcg per day subcutaneously

While only indirectly supporting attenuation of fibrogenic activity, both semaglutide and lanifibranor significantly lowered -SMA levels, Similar distinct histological benefits of semaglutide and lanifibranor monotherapy have recently been reported in GAN DIO-NASH mice without HCC (treatment start after 3438 weeks of GAN diet feeding, fibrosis stage F1-F3) 20 , which is in close agreement with primary endpoint outcomes in corresponding clinical trials in NASH patients with fibrosis (stage F1-F3) 25,26

Enhancing satiety: It increases feelings of fullness, making it easier to consume fewer calories and lose weight over time