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Weight-loss medications in the 20th century proved to be equally dangerous: dinitrophenol, a mitochondrial proton pump uncoupler, was remarkably effective at shedding pounds but led to nerve malfunction and arrhythmia induced fatalities

SURMOUNT-1 (tirzepatide) data SURMOUNT-1 (N=2,539) tested tirzepatide 5, 10, and 15 mg against placebo over 72 weeks, reporting 15.0%, 19.5%, and 20.9% mean weight loss at the three doses respectively [2]

86,180 This suggests that supplementation alone may not reverse the profound metabolic changes caused by malabsorptive surgery, necessitating tailored interventions

Tirzepatide: A Dual Glucose-dependent Insulinotropic Polypeptide and Glucagon-Like Peptide-1 Agonist for the Management of Type 2 Diabetes Mellitus