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Since previous studies have linked the activation of NRF2 with the repression of lipogenic gene expression 64 , we reasoned that GSH depletion causes oxidation and consequent inactivation of KEAP1 (a repressor of NRF2), thus leading to increased antioxidant and decreased lipogenic gene expression
Subsequently, reduced inflammation was achieved via administration of NLY01, a GLP-1RA, resulting in lower levels of RGC death and astrogliosis
Its like discovering that the first responders at a local clinic are also trained to rebuild entire hospitals
p53s essential function of survival promotion is confirmed by the fact that cells are more sensitive to ferroptosis after p53 depletion through CRISPR/Cas9 (Tarangelo et al., 2018)
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