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ER stress is counterbalanced by unfolded protein response (UPR) which reduces the misfolded protein load via ER-associated degradation (ERAD) pathway 8
Peptides are shipped as powder because they're more stable in this form
The pharmaceutical formulation disclosed herein may comprise hydroxypropyl-beta- cyclodextrin having a molar substitution range of 0.58-1.0 hydroxy propyls per glucose unit
Group I was induced with TBI and treated with DMSO at 67.5 mg/kg orally once daily which started 30 min after the induction of TBI and lasted 21 days
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