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Patients should stop tirzepatide and seek immediate medical care if they experience severe, persistent abdominal pain (which may indicate pancreatitis), symptoms of gallbladder disease (right upper quadrant pain, fever, jaundice), persistent vomiting leading to dehydration (which may cause acute kidney injury), or signs of severe allergic reaction

Clinical studies and meta-analyses have identified an increased risk of gallbladder disease with GLP-1 receptor agonist use, particularly with weight loss medications

However, inform your healthcare provider about any peptide use, especially if you're on medications affecting copper metabolism or have copper-related conditions