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The choices made by manufacturers racing for market share and regulators enforcing Schedule M standards will determine if this is a model for affordable access or a cautionary tale

This raises the notion that perhaps within konzo-prone regions of sub-Saharan Africa there may be genetic variants of GPx3, or genes related to associated pathways that circulate which could alter gene expression and subsequently cause a reduction of protein abundances in these populations

4 Discussion This systematic review and meta-analysis provides an updated and detailed evaluation of the effects of semaglutide on arrhythmic, major CV, and microvascular outcomes in patients with T2D