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doi:10.3389/fnmol.2017.00144
It differs from native IGF-1 at two positions: a 13-amino-acid N-terminal extension and substitution of arginine for glutamate at position 3
2 Challenges of developing an oral peptide therapy The oral administration of peptides is not a new concept, and the challenges faced are best illustrated by considering the failure to date to produce a marketable oral formulation of insulin since its discovery in 1921 [1, 2, 8, 40]
I know quite a few derms are out there speaking out on this exact topic, saying the marketing is wrong.
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