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Indeed, while efficiently inducing ferroptosis in different tumor cell lines, RSL3 and ML162 were found to also acts on TXRND1, an important detoxifying enzyme whose inhibition can also trigger apoptosis and/or ferroptosis [51, 52]
Where possible, COEM uses preservative-free IV ingredients of the highest quality for optimal absorption and effect
Its interaction with the enzyme results in JNK activation and c-Jun phophorilation 106
The peptide also demonstrates rapid desensitization, losing effectiveness within weeks of continuous use
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