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The peptide appeared to induce activation of ribosomal genes and decondensation of the heterochromatin
The mitochondrial AST enzyme is encoded by the GOT2 gene which is located on chromosome 16q21 and is composed of 10 exons that generate two alternatively spliced mRNAs encoding precursor proteins of 430 amino acids (isoform 1) and 387 amino acids (isoform 2)
However, this widely accepted assumption remains largely untested because of challenges in physiologically manipulating hepatic GSH levels during disease development
