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Epitalon Free Peptide The sequence is H-Ala-Glu-Asp-Gly-OH, commonly abbreviated to AEDG

The modulation of GABAergic neurotransmission by neurosteroids is mediated by interactions with allosteric sites on GABA A Rs (105109), and neurosteroids appear to play a role in regulating the expression of specific GABA A R subunits ( PregS is a relatively potent positive allosteric modulator of NMDAR-mediated synaptic transmission, while pregnanolone sulfate is a relatively potent negative allosteric modulator of NMDAR-mediated glutamatergic neurotransmission (110)