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It's to find the minimum effective dose where you have meaningful satiety suppression with manageable side effects

In Arabidopsis thaliana exposed to combined high light and heat stress, anthocyanins accumulate preferentially in photosynthetically active leaf tissues experiencing elevated oxidative pressure, indicating that flavonoid deposition is coordinated with local physiological requirements rather than occurring uniformly throughout the plant (Balfagn et al., 2019)

Sipping fluids slowly and consistently throughout the day is generally better tolerated than consuming large volumes at once, which may exacerbate nausea

All of these can help you push forward, but you do still always run the risk of reaching a plateau again further down the line