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While it has been previously observed that fibroblast-derived matrices amplify the osteogenic differentiation of MSC, and this effect can be attributed to collagen type I 24,27,28,29 , at this time, we can only speculate about a potential dual role for the effect of a collagen type I matrix on osteogenesis, promoting the differentiation at moderate levels as those observed in a control matrix, while inhibiting under LOX/BMP1 supplementation

Subcutaneous injection may produce localized redness, minor swelling, or bruising at the injection site, which resolves within 24 to 48 hours

Dahnhardt et al, in 2024, conducted a pilot study in Germany investigating the effects of a 12-week administration of a custom nutraceutical supplement (given daily) that contained special collagen peptides on the structural properties of the collagen fiber network in human skin [47]

These are standard precautions and regulatory review will determine the full contraindication and warning profile ahead of any potential market authorisation