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Contraindications across the group commonly include pregnancy or breastfeeding and being under 18, with additional considerations such as active or recent cancer (CJC + Ipamorelin, IGF-1 LR3), active malignancy (Sermorelin), uncontrolled blood sugar disorders (CJC + Ipamorelin), uncontrolled metabolic or endocrine disorders (IGF-1 LR3, MOTS-C), severe liver or kidney disease (MOTS-C), autoimmune disorders requiring careful metabolic regulation (MOTS-C), and use of insulin or oral hypoglycaemic medications due to hypoglycaemia risk (MOTS-C)
doi: 10.1093/sleep/zsab276
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Elevated LPS levels trigger systemic inflammation by activating toll-like receptor (TLR) 4 on immune cells, subsequently inducing the release of pro-inflammatory cytokines such as IL-6, TNF-, and IL-1 [145,146,147]
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