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Endometriosis is a chronic and debilitating disease that affects around 10% of all women of reproductive age
These monotherapy results established proof of concept that amylin receptor agonism alone can produce clinically meaningful weight reduction and informed the dose selection of 2.4 mg for the combination product CagriSema
Patients should be advised to take bulk-forming laxatives with adequate fluids (at least 200250 ml per dose) to avoid oesophageal or intestinal obstruction, and to separate them from other oral medicines by at least 2 hours
Effects may be less dramatic than the first course if the initial burden was substantially reduced Maintenance: Some community protocols transition to once-yearly courses for ongoing senescent cell management There is no research to validate this approach
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