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Age is a significant factor
Patients with chronic liver disease, especially liver cirrhosis, usually suffer from secondary carnitine deficiency (65, 66)
These actions enhance cell proliferation and migration, promote new blood vessel formation ( angiogenesis ), and accelerate wound closure in injured tissues
In addition, multiple transcription factors, such as ATF3, ATF4, P53, Nrf2, and c-Myc, have been identified as the regulators of SLC7A11 and SLC3A2 transcription [11, 27,28,29,30]
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