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doi:10.1007/s11064-012-0895-x Lin JB, Apte RS

Importantly, evidence supporting the hypothesis that tirzepatide targets the physiology of energy balance, including its action on central regulation of food intake, continues to grow

Further electrophysiological study showed that, opposite to the effects on arcuate POMC neurons, GLP-1 hyperpolarizes arcuate NPY neurons indirectly via increased GABA A receptor-mediated neurotransmission of local GABAergic interneurons (Secher et al., 2014